It's very very easy. I breed gerbils for a friend of mine, and by the time the first litter is eaten, there's a second litter already growing up and ready by the time the snake is ready to eat again. Very convenient. I have them gerbils in a 10 gallon tank I got at a resale shop for $7, and then made a screen lid. I feed them a variety of food such as the regular gerbil diet, veggies and occasionally dog food which is great for their teeth, to make sure they are healthy and fat. Also to make sure they are healthy, I recommend going to the vet and getting a fecal done on the parents just to make sure, the parasites they usually get are pinworms, tapeworms, and coccidia(protozoa). Pinworms aren't too bad, and can be diagnosed pretty easily by sticking a piece of tape to their little hiney and putting that under a microscope(done by the vet) I keep the father gerbil in there, and he has never tried to eat the babies, and he actually takes better care of them than the mom does, but he might be a rarity. I would probably recommend taking the dad out after about a week of being in with the mom, so she can be alone and take care of the babies when they come. I'm not quite sure on gestation period, but it seems to be only a few weeks after mating you see babies. The most I've seen out of gerbils are 8, but it can vary alot. Rats can have up to 20 at a time, and I have no clue about mice. Probably around the same amount. *This info is for breeding enough for one snake* If you need to breed multiples, I would invest in one of those Freedom Breedom racks or just have a couple 10-20 gallon tanks around if you could somehow build shelving for that. If possible, keep one mom rat/gerbil/mouse per 10 gallon to avoid fighting over the babies. This helps keep the stress level down. And with the dad rat/gerbil/mouse keep him in a tank/cage by himself so there's no eating of the babies, which is very sad to see a baby mouse's head being torn off. Females kept together will also do this, so try to keep it down to one female per tank as I stated above. I'm sorry this is such a long post, there's just alot of info. At least it isn't difficult to breed them. Well happy breeding and Good Luck.