Getting a snake was actually my girlfriend's idea so she's fine with it. 90% of everyone else....not so much.
When we went on vacation last year I asked my mom if she would come over and check on him every day or so. Her first response: He's going to eat me! So what I did was have her come over for dinner a few weeks before we left and after dinner I got him out without telling her. It took about five minutes before she was asking if she could hold him and that was the end of it. Now she refers to him as her Grandsnake. With most people, all it takes is one good experience and a little education.