I have read of some instances where folks have built with a second access behind the hide so that when the snake is in the hide they can slide it out of the side and secure it while cleaning the cage. A seperate room would be a crapshoot every time you opened the door UNLESS you had one with a plexi/reinforced window or a half door so you could look in to assess before opening the door - Randy makes a damn good point there: some snakes are "cage defensive" and if that whole room pretty much belongs to the snake . . .

Judy makes a second extremely important point: if a 15'+ constrictor throws a few coils and manages the chest you had better pray you have backup. Of even more common and practical note for even the most docile big'uns you cannot properly support a snake of that size on your own - they'll need another couple support points (and obviously shoulder/neck isn't on the reccomend list). The common giants are thick with heavy muscle and strong. If you managed to grow a scrub that big it would tend to be slimmer but easily make up for that with speed and agility.