I've taken a nice bite from one of my big girls who was in a feeding rage when I opened the tub. She jumped out and tagged my hand and locked on chewing. Back fangs pierced my skin and it bleed pretty alright. I took a benadryl as a precaution, but didn't really sweat about it . . . no swelling, no nausia, no pain other than the bite itself. No hurt feelings or mixed emotions ;-)
Side note: My girlfriend was tagged hard by a rear fanged venomous Leptophius (Parrot snake) in Panama this past september. It bled a decent amount, but even with it being a wild snake, with more dangerous venom than hognose contain, it was still a no reaction bite, but loads of blood as it chewed for a good 10 - 15 seconds.
Unless there is a history of reactions to bee stings, or alergy prone in general, it would be a 0 threat level. As others stated, bites from hoggies are a rare occassion! They usually strike mouth closed. My bite came from feeding initiation. You can see how my hognose acted when they were younger! I'll upload an updated video with my 375+ gram female :-)
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