I've got 2 AP cages stacked on top of each other, and one of my snakes is always out of her hide and ready to strike the SECOND she hears the key hit the lock on the cage above her.
They're both young and not quite acclimated to handling, so it's gotten to the point that I need to pacify her when I do anything in the cage. Last time I wanted to pet her I made sure to wash the hell out of my hands so they'd smell soapy, and then I opened up her cage and sort of slowly moved my hands in with my face directly in her line of sight, the whole time breathing heavily at her so she'd smell me her and repeating, "See? I'm not a rat. If I was I'd be HUGE." Eventually she relaxes and I can pet her a little.