I would like to chime in on this thread because every person I see speaking on this topic says the same thing: "Wild mice could have parasites and diseases that could hurt your snake!!!!" etc.

First of all, reptiles cannot get certain diseases that mammals can. I am certainty not an expert on this subject, but until I see someone posting some laboratory research on this topic of which parasites and diseases you are talking about and showing that said parasites and diseases are harmful to reptiles I am going to be skeptical about it. Snakes in the wild eat wild mice exclusively and people have witnessed plenty of adult snakes so there is at least some proof snakes can eat wild mice. They have highly acidic digestive systems that I can only imagine will disinfect much of what they eat even if it was diseased. It is hard for me to imagine that feeding a captive snake a few wild mice every now and then will effect it's health too much. Furthermore, just like any animal they have immune systems. Snakes have a tolerance for parasites and bacteria that they ingest every day. Nothing is 100% sanitary. Snakes must be at least somewhat resistant to diseases they encounter in the wild. They do have quite a long life span.

In the southeast we eat all kinds of wild animals that we cook thoroughly and no one ever gets sick from it. Perhaps if you really wanted to be sure you could boil cook the mice and then let them cool to serve to your snake as it would kill any parasites or bacteria living in them. You would probably have to make sure to use a thermometer to check the boiled mouses internals after though to make sure you weren't going to burn your snake. I think that underneath all these cliche responses is a reoccurring theme that eating anything from the wild is toxic and risky. I think people are too spoiled these days in thinking that everything is clean and sanitary coming from factories where things are made artificially while not realizing the FDA and other regulations allow for things like bug parts per million to be allowed into our food.

Would I feed wild mice to my snake? Perhaps I will experiment feeding wild mice to my regular regius and see how it goes. That is what actually lead me to this forum. I think I would try it since all I ever see is the same pretentious response that everyone gives without any supporting information.