The only "trouble" we've had with any of our snakes is that our younger ball python seems to prefer fresh-killed to frozen/thawed. Also, curiously, he seems to prefer white mice over black ones. We just got a shipment of frozen black mice this week, though, so we're going to have to work a little harder to get him switched over.

Other than that, all of our snakes have been really good eaters so far (knock on wood).