Well, I personally believe it depends on the personality of your BP. When you first get your BP, you're going to want to wait until he has fed and is feeling comfortable in his home. After that, you're not going to want to handle for a day or two after feeding. If he is irritable during his sheds, leave him alone then too, but many BPs are fine during their sheds. Otherwise, you can handle your BP as often as you like without stressing him out. My baby is comfortable being handled just about everyday for any amount of time, and even seems to enjoy it--he is an active, silly guy. It's all going to depend on your snake.