With something as noticeable as a super blood, the odds of genetic corruption are low. Although, I think breeding them back to one species is going too far, what people usually breed are 50/50 hybrids. I, personally, want to establish "pure" 50/50 superballs as a domestic subspecies, after a couple generations of selective breeding and stablizing genetics.
What I believe is a problem with hybrids and integrades are closely related species like carpets, boa constrictors, and short taileds. However, even a Mongrel ball (25% blood 75% ball) is distinguishable among other pythons. F2 Superballs look wicked cool.