I don't know if "frodent" was intentional or not....but it made me laugh...
It was, I came across that term somewhere on the vast internets and loved it.

Is there an issue with simply running a frodent under warm water to defrost it?
You could as long as it's done within a reasonable amount of time. I base all my info on the fact that it is a meat product, and you should treat it the same way you treat human food. Yes, I realize that these are animals and may be adapted to eating "less than fresh" food in the wild, but why risk it? No one knows the facts in regards to wild snakes eating carrion and dying (or not dying) from it.