We have to vacuum the floor a couple times a week to take care of the bedding they knock out, and do a more detailed cleaning once every couple months to keep the dust down. But we live in the desert so it's dusty here in general all the time!
With our BP's it doesn't effect them at all, except when we move a new animal from QT into the main reptile room. Some will be alittle bit more active/food hunting at first. But no worse than a building female or female who's back on food after laying who wants to come out of the tub looking for food any time you open it!