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For a pet, I would suggest real bedding and spot cleaning the bedding. This way you can spread out larger, full cage cleanings. However cleaning does have to be done.
If on newspaper, then more cleaning will be needed. When you get into racks with lots of snakes, you don't want one animal to get sick in there with all the rest, so cleaning is more important there, especially again if newspaper. With newspaper, I will clean with a quick rub down with a chlorhexidine solution EVERY TIME something has been dirtied, but that's just me. If the paper is just crinkled up, or is hardly a spot, I may cheat and just change out paper, but anything more I do a clean. I am strict about my cleaning because I have had sick snakes and I hate dealing with sick snakes, so I am all about preventative measures after learning the hard way a while back what can happen, and since getting fierce about it have had no problems.
They don't need 100% sterile conditions as pets, but I don't recommend bad conditions either (in fact I do recommend sterile conditions, just saying they aren't needed). This is spot cleaning. You get the big stuff so it's not a problem, then any little residue stuck in is so minimal that it isn't sterile, but isn't harmful, and when you do the big clean it will all be taken care of.
I don't think you need to remove her from the enclosure to feed. It can stress out the snake, and I have not heard enough to feel it is worth it (and yes some will argue this). I have always fed in the enclosure. Just get the mouse poop when spot cleaning.
So do you need to do all this cleaning? well, I would suggest every so often you should. Get some chlorhexidine solution, bleach is debatable and certain plastics can supposedly react negatively to it. If using bleach, clean it out super well. Also the bleach solution doesn't have to be strong, a mere 10% bleach solution will do the trick.
Please don't just say "because your snake will get an RI or other dread disease and either die or cost you a million dollars at the vet."
But if you aren't willing to go the extra mile your snake really could get an RI or scale rot, and really could die. You can't ask people to make points and expect them not to make the most obvious and important point. If you aren't willing to do all you can to keep the snake healthy, don't own the snake.
If you wanted to get into breeding ever and I read a post stating you wanted to not do work for healthy snakes, I would never buy from you, so if that is also in your future, start getting used to being clean now.
Best of luck!
Ball Pythons.... I have a few 
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