I spray it directly on my snakes when I notice thier skin getting dull, and I continue to do so until shedding is complete. I also give them warm baths every few days to help this along, and then once they are dry from thier bath, spray them with shed ease. Another thing I have been doing for awhile now, is even when they are not in shed, I have a product made by Four Paws- Nature's Reptile Vita-Spray. Heres what is says on the bottle:

*Provides natures vitamins
*Contains Electrolytes
*Prevents drying of the skin
*Keeps reptiles healthier for a longer life

I spray this directly on my snakes 1-2 times weekly, when they are not in shed. As soon as they have shed, I use this immediately. I guess my biggest reason for this is because this product contains electrolytes, which are vital to the animals. I have found that by using this product I have less shed problems to begin with. I feel it has helped using both products in conjunction with eachother.