Yes, I'm not thinking we have been breeding ball pythons long enough to see anything like breeds in dogs. More inclined to think he picked up a nasty bug, maybe came in with some morphs? Knock on wood but I've been able to avoid RI in ball pythons. I suspect with larger collections it gets harder and harder to keep things like that out. Years ago I'd heard that most all big breeders have had at least one mass die off. Maybe the answer for large collections is to compartmentalize and somehow split them into completely separated smaller collections. That would defeat a lot of the economies of scale though.