A full grown, live guinea pig is no joke. Mine was a couple pounds - as big as ball pythons can get, they're not going to be big enough to really go for a guinea pig that size. By the time the snake may get large enough to consider harassing the guinea pig, the guinea pig is going to be big enough to not be something the snake wants to mess with. Most ball pythons barely get large enough to eat a jumbo rat...a guinea pig is even bigger than that!
-Jen
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