Can't speak from personal experience but I wouldn't. With a ball having a single lung and all, why risk it? Any way you could have a vaporizer or nebulizer in another area of your house that you could use rather than saturate the air with it? More localized instead of the entire room. Neti pots work well too. The results are...impressive, lol! I wouldn't use one in front of your significant other or with any spectators but they're great for clearing out congestion if that's what's bothering you.