2 days in 2 days out is too often to pair them imo.
I pair once a week or less often if they have multiple lock ups during the 2-3 days they are together.
Your male will burn out if you pair 2 in 2 out.
THE best time to pair a male with a female is after she sheds, I will pair at the beginning of a shed coming on, but not when the female is in blue.