I own 3 ball pythons and 5 corn snakes. I have had one of each species out at the same time, but it is not easy. I usually have someone close by to be safe. All of my corn snakes are under 2 years old and still very wiggly. Usually my ball pythons will sit in my lap while I manhandle the corn snakes, so it's usually not a problem. However, I think having one out at a time is just easier if you're not comfortable trying to jungle snakes or if you don't have a spotter in the room with you.