Generally a tap on the head will get a rat that is to curious or defensive to back off. Once in a while you do pick one up that knows there is something wrong with the scaly thing in the corner, I have had a few bury my snakes in bedding. I haven't found pre-killing to be required, just as I said, an occasional bonk on the head with a pencil or ruler, or hairbrush, whatever I have handy.
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