My pine snake never fails to rattle and hiss and do all sorts of acrobatics when I open her enclosure, but is absolutely fine once I've got her in hand. Silly thing.
Nova (female fire BP) will also hiss and get into strike pose almost every time I open her tub. While I know the bites wouldn't hurt, I don't go out of my way to -get- bitten, so I'll usually let her watch one hand while I scoop her up mid-body with the other. Absolutely fine once that's done, should probably change her name to drama queen.