We generally spot clean each tub about 3 times a week. As for our big clean, every 2 weeks we wash the tubs with Dawn, then spray down with F10 and let air dry completely. Replace substrate and move on. We also use disposable deli cups in our tubs for their water so each snake gets a new cup weekly unless they use it as their bathroom and then we replace it immediately. Hope this helps, it works for us.