Sick building syndrome is basically modern buildings that do not have enough ventilation it results in respiratory issues in the people working and living in them. Enclosures with too little ventilation can have a similar effect on snakes. I can't tell you how much is too little. I understand the need for conserving heating dollars, I feel it is important to note this is a possibility. I am not saying you don't have enough I am just saying be aware that there is such a thing as too little.