Even my most neurotic baby ball pythons seem to be okay with handling after several years of it off and on. I do have two or three ball pythons that I think were handled from day one by their breeders, who actually seem to LIKE it. My male pied will climb right on to my hand. My female lucy likes come out during card games so she can climb on top of the discard pile and periscope around at the players. And Glinda the pastel has been described as a "flirty sorority girl", because she seems to like men.
The rest of them seem to be more tolerant than actually enthusiastic about it. But they'll all perk up at the opportunity to climb the bookshelf and knock my stuff down.
The boas I've met in pet stores seem to be super-interested in coming out to play. Though again, I think they mostly want to climb the shelves and explore.
I think a lot of it is handling them young, and consistently, and never giving them a reason to not like you. And maybe a lot of it is just luck of the draw.
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