Yeah, depending on what kind of course work you are interested in online classes are not always a smart option, though it may look good on paper. The best approach in my honest opinino is to find your local university, or at least within a reasonable driving distance, and talk to an advisor there about enrolling in online classes through that university. If you are talking about "University of Phoenix" or something, employers will typically discredit your education, heck there may be even a special place for that on some employers check boxes during interviews this late in the game. None the less, if you can enroll in online course work from a local university that has you come in within a set amount of time to take your test in person, and attend lectures once a week in an online chatroom, this will be FAR more credible than the other online options out there.
The only degree I know a lot of people push getting online is a teaching certification, which still requires you to go to a testing center for certain qualifacation exams, and requires you to still do your in class time with an actual classroom of students. These seem to hold their own fairly well, but mainly for those who have already attained a degree and are just adding the teaching certification as they can.
Have you looked into advance learning night classes that may fit your schedule and allow you to take 1-2 classes a semester and slowly get your credits you need? Also, I'm not sure how it works in your state, but some states have an expiration on your credits if you fail to complete a degree. In Texas you have 7 years from the start before you have to retake your pre-requesite course work.
Being as this is a reptile forum, if you'r'e more interested in going with a degree in something like Biology or Natural Science, online classes will not get you there, the amount of laboratory course work needed will make it impossible, outside of some classes that is like GIS.
Hope this helps!