Does not handling your bps for extended periods of time (like 4 days in a row) cause any potential problems like them becoming agressive?

I check on my snakes every morning and every night for any messes in their cages and always change out their water but lately I've been soo busy I haven't really been able to spend quality time with each of them. I feel guilty about it.

Will this cause any problems with them or is this in any way neglectful towards them.

Thanks.