It can be frustrating. I've just come to expect numerous refusals from my ball pythons at this time of year. Most of the females are eating fine, but right now all of my males except for the baby have been refusing food. I think you get to a point that it doesn't bother you anymore, knowing that its typical and that bigger ball pythons can go months without food with no ill effects. At this time of year I just thaw slightly over half as many prey items as pythons and offer prey to everyone weekly. I keep my boas on the same feeding schedule, and they are happy to eat up any leftovers, so there is never any waste.
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