There are a few combos that just don't survive or are complete train wrecks! Kevin from NERD's lethal combo videos are pretty good because he gives several things that you want to avoid crossing. Including Champagne x Spider.
As far as the Pearl goes he actually talks about that and how he has what he is calling a Soul Sucker Pearl that is alive and doing very well. He's just not sure if it's from the outsourcing of different genetic stock or because there are so many different genes combined that it is "neutralizing" the negative effects.
http://www.youtube.com/watch?v=uStCAKMbnqQ
http://www.youtube.com/watch?v=-fhnR5YdGdI
Here are the videos if anyone is interested.
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