The biggest difference is that you have to flash all of the components with EFI firmware. This can be very difficult and takes a long time to find/get working. I've personally gotten rid of my hackintosh now that I have a 2010 hex core Mac Pro with 24 GB of RAM. But I am using non-apple graphics cards. I have 2 NVIDIA Quadro 5000 GPUs that I flashed with the apple supported Quadro 4000 drivers/firmware.