First, you need to make certain both are healthy and up to proper weight. Then you should make certain they are indeed a male and a female.
Once you have them set up in thir seperate habitats, proper heat and humidity and feeding well on a proper size prey item regularly... then you can start thinking about the breeding process.
Before you breed, do you have a incubator? Do you have space for up to a dozen individual shoebox sized habitats for each baby snake that might result? Do you have homes arranged or a place to sell the babies? Is it legal to sell pythons where you are, or do you need a license or permit?
Once you're sure you have everything set up and you're ready for breeding and the snakes are healthy and in good weight, then you can drop the temps slightly, then try introducing the male to the female. Storms and storm fronts seem to incite some breeding response in some snakes, just as a tip. They may not breed, they might breed immediately. Once you've seen a lock, you can seperate them again. When the female ovulates, you know you should be expecting eggs.
The set up is way harder than the actual "how to breed" is.