My BP hissed at me for the first time when I went to go spot clean her tub and moved her around a few times to get her out of the way. It surprised me but she didn't strike or anything. Ever since then she hisses at me every other time I go to get her out and handle her. I see it as a "Hey, I'm comfortable what do you want?" type thing because once I have her out she's chill and starts getting all up on me lol