A LOT of ball pythons are bred in the pet trade, and a lot of them are very domesticated.
I figure this is because of the breeding intervention... ball pythons in the wild have a lot of eggs in a clutch because most of them won't survive. The ones that do are the most "genetically superior" but because we have a vested interest in the animals, we ensure that (to the best of our ability) all of the animals survive. Even those who wouldn't have survived in the wild due to appetite, etc. And those animals breed and pass on their genetics.