Siamese are not any more prone to carrying the high white gene than any other color of rat.
Mega colon is caused by the dominate form of the high white gene, all of my rats are recessive high white so I have no issues with mega colon at all.
Odd eyes are a result of high white, as are blazes, head spots, and any rat that has white where it's not suppose to be.
If you got mega colon babies from an odd eye rat then you've got dominate trait high white, something that I would feed off...