I don't have any sort of schedule with handling. My two older pythons get held a couple times a week sometimes, and sometimes I don't get around to it for a month between work and other obligations. Doesn't seem to make a difference for them, never bitten anybody and though my mojave is more comfortable with people they're definitely both able to be out a few hours with no ill effects. I've only had my little fire female for a month and she gets held daily, being in the bedroom it's very easy access. She's less and less nervous with each "session," so I imagine she'll be tamed down soon. Pretty mellow (if a bit reserved) to begin with anyway