What works for me everytime...

I take a towel, soak it in pretty warm water...not hot...and wring it out real well.

Then I take a tupperware container (about the size of a medium kritter keeper so the towel is slightly snug in there) and I put the python in the container over night.

I've had one of my females have a bad shed...shed off in small spots, didn't quite look like she was shedding in others, skin just hanging on in places, for about a week...I did this and the next morning it was literally all off in one (albeit it messy) single shed.

I was scared for her, like i did not think it would be possible for it to come off in one solid piece with the shed she was having, but it did. Since then, i've used it everytime i have the hint of a bad shed lol