I guess I'm missing what's complicated about the subject? The question was are we nearing the end of guaranteed genetics.
And no - I don't think so. Double and triple combos are going to be going strong for a LONG time now. Those who will be dealing with the larger number combos are at this time, an elite number of folks.
Though - if you think about it - all these base mutations that we have to play with are a little like leggo's. Every person can make something completely different with the same "starter set". The limit is up to that person's imagination.