I recently got my first ball python so I know what it's like to try and figure everything out.
As for time to care for it, so far I have not had much of a problem. Feed once a week, change the water and mist once a day (that's the only tough thing I've had to deal with is trying to keep the humidity high enough). I even bought timers on my lamps so that I don't have to worry if I'm home later one day.
And as far as handling, my snake was from a petstore so I'm still trying to get her used to being held and such but as long as you've given time for digestion I've heard people say you can handle everyday but a snake wont mind if you don't.
Good luck!