Anoher technique I use is that I will ALWAYS use hand sanitizer before I pick them up, or change water, or spot clean the enclosure (of course making sure rub my hands until there is no more wet hand sanitzer and my hands have dried). I have two guys that use to shoot right out of their enclosures when I first got them and was simply changing their water but now I can reach in with no sign of that defensive move. The only time I don't use hand sanitizer is on feeding day and on that day I don't mess with them at all.