I laugh at them a bit sometimes, because they're a little uncoordinated and goofy. It doesn't appear to bother them, so why should it bother us?
If they were bothered, they would show signs of stress, such as poor appetite, failure to breed, etc. They show no signs of stress at all--they tend to be good eaters and good breeders.
I think perhaps it reminds some people of tragic disabilities such as MS and Parkinson's disease, and that's why they feel uncomfortable about it. But it isn't a real disability for a snake that will live its life as a pet.
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