I try to focus on life's small joys and the journey rather than the goals and bigger things which are often a source of frustration.
The feel of a good stretch or yawn
the feel of jeans on your skin
the softness of a blanket
the play of sunlight on the floor
the obliviousness of an animal
the smell of summer air
the sensation of a hot bath
try to recognize despair as a chemical interaction in your brain, not as reality
and get help! seriously!