Depending on the ball python itself you can handle for much longer than 20 minutes (not at first of course, you will need to work up to longer periods). I have one that I can take out with me (in 75*+ weather of course) for hours at a time while I'm running errands. He's always a good conversation starterThose three times are definite no-no's, but other than that if they are social and tolerate being handled in the house I see no reason why you can't have them out for extended periods of time. They probably don't enjoy it, but my Julius doesn't seem to mind. He just hangs out around my neck and tucks his head behind my hair lol. I do have bps that I don't take out for long periods though because they are a little high strung to begin with and I don't want to give them any more reason to not eat for me lol.