My previously neglected 4yr old male was very "nippy" when I took him in because he hadn't been handled (literally) in years. Now, he's still a bit jumpy but doesn't hiss or strike anymore. My point is, if a four year old could be "tamed", as you put it, then there's no doubt in my mind a 2yr old can. Like has been said, you can't be afraid to take a couple tags.