I handle some of my snakes more than others but all of them are pretty mellow. I know that I can ignore (barring changing water and dropping a rat in the tub) some of my snakes for weeks upon weeks and when I reach in to pull them out, it's no different from other snakes that I've handled on a more regular basis.

Snakes, just like any other animal, are bound to have their own personality quirks. Some are born little spit fires that never seem to settle down and consider everything that moves around them a potential threat. Others start out as defensive babies and grow in to laid back adults. Others still are born without a care in the world and don't seem to mind being handled at all.

I don't think it's fair to assume that every snake will react to a given scenario in the exact same way. Some, like mine, don't really care whether you handle them regularly or not. Others may become more defensive over time if no direct attention is paid towards them. And, of course, you'll always have the spit fires that really don't care how often you want to try to handle them. They'll try to nail you every time.