By any chance are they living together? What's their setup like? If they are living together separate them asap. Her response tells me she's stressed. They don't often miss. Except for learning babies and snakes with neurological problems they are pretty dead on. But That sounds like defensively striking. So what's are the temps? How long have you had them? And what's the set ups like? It sounds like the female and even the male have either been cooling and then very stressed when they werent in cooling. They shouldn't be going that long with out eating though. Has their weight been monitored? Hopefully it has been or else there is no way to tell if they lost dramatic weight and theres something to worry about.