I'm working with pieds and hoping to do some cool double recessive and recessive+super projects with them. Which happen to be the same cool projects everyone else is working on, and there's ALREADY a tendency to inbreed recessives. So yes, I'm worried about it --- I'm planning to deal with it by mixing lines (ie. Kahl pieds with Kobylka pieds, watching for people with new lines from Africa, etc.) and eventually by breeding multi-gene morphs back to imported normals to get some new genetics into the hets via outcrossing.

THAT SAID: I'm not seeing inbreeding depression in the majority of the morphs out there. I think we're seeing it in some boa morphs, but not in ball pythons. The spider wobble and caramel kink both seem resistant outcrossing or line crossing--especially the spider gene, which is a dominant gene, and one of the most outcrossed morphs out there. Yet every spider still has at least a little wobble? That says something pretty clear. And what it says is: the wobble is tied to the spider gene, and can't be easily pulled out with good breeding practices.

It could be lessened with line-breeding however--repeatedly selecting for spiders with low wobble, generation after generation. But that's quite a big project, and wouldn't pay out quickly or much, so we may not see it happen for a while.