First off, I'm sure you will get varying responses to this. However, all of my gtps are very easy to handle (I haven't been tagged yet!) day or night, as long as they are given some warning first. I have found them very easy to care for as long as their cages are set up adequately. Of course "easy" is a relative term, I'm sure they are relatively more difficult when compared to other species (corns, etc.) If you do you research and have a cage set up and established beforehand you would probably do fine, even if you chose to get one as your first snake.
This first girl was a WC expo purchase/rescue. I was told by the wholesaler that she was imported last March. I purchased her one month later in April and she has been a complete angel...I'm sure part of this is just plain luck, but I'm also very careful about how I handle her, especially for the first 10 min or so.