It depends on what is wrong with the animal. If it's poor quality, has one small kink, etc then culling is probably not the answer. Last year my entire clutch was a train wreck. Missing eyes, kinks out the ying yang, and split bellies. After speaking with a lot of breeders, I decided to cull. One breeder made a great point, "you do not want these things getting bred and the only way to guarantee that is if you keep them all." It was a really hard thing for me to do, but culling was the best choice IMO.