I have to say, I voted No; but it was a hard decision. I don't really agree with pleasure handling as they are quite fragile and things can go wrong. Imagine for a moment, the Tarantula becomes afraid and bites it's keeper, well..it's only natural, but most people will send the little guy flying or squish it.

So, I mean if you are an advanced keeper and setting with a pillow on your lap or something and you are confident, can it be done? Yes. I'd just use caution and be aware of the species and it's medical significance and temperament before even thinking about it.