Ok downsize to a 15 quarts tubs, get a DIGITAL thermometer/Hygrometer (analog are far from being reliable), provide 78/82 on the cool side and 88/92 on the warm side, and no more handling for a while.

The aggression is stressed related the cause can be found in your husbandry and happened over time.

Quote Originally Posted by ewelch View Post
He is in a 40gL breeder with three hides. His temperatures range from 98-78 (they are measured analog), I handle him about 4-5 days a week, and I feed him live jumbo mice every 5 days.