Thus far there has been very little evidence of issues inbreeding ball pythons (or other snakes for that matter).

If you have any morph, like the spider morph, that animal is many generations following form the originally found spider. There are LOTS of spiders out there. Same with pinstripes, pastels, etc.

Hillbilly is kind of an odd term for you to use. Humans who inbreed generally don't become "hillbillies" which indicates stupidity. Extra limbs or genetic diseases are more likely.

There are definitely some things that are related to this topic. Spider wobble is genetic, so is in all spiders to an extent because the first spider had the gene, but can be selected out of certain lines as well. All in all, you have nothing to worry about. Breeders inbreed for lots of generations without any issues.
I would recommend introducing fresh genes every couple generations, but you're probably not going have to worry about that unless you become a big time breeder.