Only problem I would see in that would be the plexi top and in the middle of the room.

Plexi top might scare the snake when putting stuff down on it constantly and cause stress

It being in the middle of the room (I assume b/c most coffee tables are unless it's an end table) might have to much foot traffic. Again I don't know how many people come over or if you have parties, etc. It's a might cause stress situation.